Medical College of Wisconsin - Pathology
An excellent training opportunity for junior/senior post-doctoral fellows is available in a dynamic cancer research laboratory. The candidate will investigate Jak-Stat signaling in prostate/pancreatic cancer diagnostics, progression and therapy, and how Jak-Stat signaling promotes cancer progression to therapy resistant metastatic disease using human specimens as well as PDX and cell culture models. One area of current focus is on Stat5 regulation of DNA repair in prostate cancer. Marja Nevalainen’s group provided the proof-of-concept that Stat5 is a therapeutic target protein for prostate cancer. Her group demonstrated that Stat5 controls prostate cancer cell viability and castrate-resistant prostate tumor growth, and Jak2-Stat5a/b signaling induces simultaneously epithelial- mesenchymal transition and stem cell-like properties in prostate cancer cells. Dr. Nevalainen lab further discovered that the Stat5 locus is amplified in castrate-resistant and metastatic prostate cancer, followed by an important translational finding that elevated active Stat5 in prostate cancer prior to intent-to-cure radical prostatectomy predicts development of castrate-resistant and metastatic spread of the disease in patients. The Nevalainen laboratory recently identified a family of novel small molecule Stat5 inhibitors with high efficacy in both prostate cancer and Bcr-Abl-driven leukemias. Current work on pancreatic cancer is focused on development of a test system to predict responsiveness of clinical pancreatic cancer to different available pharmacological therapies to assist the selection of an optimal therapy. This postdoctoral training position includes a strong support from the mentor for career development toward an independent investigator status.
KNOWLEDGE, SKILLS, & ABILITIES
Applicants must have motivation, communications skills, knowledge of scientific approach and methodologies, and ability to design and coordinate scientific research projects. The candidate is required to perform cell culture experiments using various methodologies. The fellow may also be requested to handle laboratory animals to understand basic biochemistry and techniques that apply to protein expression and purification. These techniques include tissue culture, transfection, Western blot analysis, RNA isolation along with other state of the art molecular, biochemical, immunohistochemistry, genomics and imaging methods. Trainees will receive training in a broad range of research methodologies and in writing scientific publications and grants. Studies involve in vivo and in vitro models of prostate and pancreatic cancer. Successful candidates must be organized and be able to work independently. Salary is dependent on experience and follows NIH-guidelines. This postdoctoral training position includes a strong support from the mentor for career development toward an independent investigator status.
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